Prepulse Inhibition Test
behavioralmouseDAP12-deficient (DAP12−/−) mice
Objective: Assessment of prepulse inhibition as a measure of neuropsychiatric phenotype in DAP12-deficient mice
Protocol Steps
1
Prepulse Inhibition Assessment
Conduct prepulse inhibition testing on DAP12-deficient mice to measure neuropsychiatric phenotype
Not specifiedNot specified
Note: Prepulse inhibition is described as impaired in DAP12-deficient mice and is commonly observed in several neuropsychiatric diseases including schizophrenia
View evidence from paper
“the mutant mice also showed synaptic degeneration, impaired prepulse inhibition, which is commonly observed in several neuropsychiatric diseases in humans including schizophrenia”