Prepulse Inhibition Test
Objective: Assessment of prepulse inhibition as a measure of neuropsychiatric phenotype in DAP12-deficient mice
This is a Prepulse Inhibition Test protocol using mouse as the model organism. The procedure involves 1 procedural steps. Extracted from a 2003 paper published in Journal of Clinical Investigation.
Model and subjects
mouse • DAP12-deficient (DAP12−/−) mice • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Prepulse Inhibition Assessment
Primary readouts
- Prepulse inhibition response
- Neuropsychiatric phenotype assessment
- Comparison of prepulse inhibition between DAP12-deficient and wild-type mice
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Prepulse Inhibition Assessment
Conduct prepulse inhibition testing on DAP12-deficient mice to measure neuropsychiatric phenotype
Note: Prepulse inhibition is described as impaired in DAP12-deficient mice and is commonly observed in several neuropsychiatric diseases including schizophrenia
View evidence from paper
“the mutant mice also showed synaptic degeneration, impaired prepulse inhibition, which is commonly observed in several neuropsychiatric diseases in humans including schizophrenia”