Source Paper
Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M<sub>1</sub>Muscarinic Acetylcholine Receptor
Tsuyoshi Miyakawa, Masahisa Yamada, Alokesh Duttaroy, Jürgen Wess
Journal of Neuroscience • 2001
Prepulse Inhibition
Objective: Evaluation of sensorimotor gating through the inhibition of startle response by a preceding stimulus in M1 receptor-deficient mice
This is a Prepulse Inhibition protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2001 paper published in Journal of Neuroscience.
Model and subjects
mouse • M1 receptor-deficient mice (M1R−/− mice) • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Prepulse Inhibition Assessment
Primary readouts
- Prepulse inhibition response
- Startle response inhibition by preceding stimulus
- Sensorimotor gating function
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Prepulse Inhibition Assessment
Subjects were tested for prepulse inhibition as part of a behavioral test battery to evaluate sensorimotor gating. The test measures the ability of a preceding stimulus (prepulse) to inhibit the startle response to a subsequent stimulus.
Note: This test was conducted as part of a comprehensive behavioral phenotyping battery for M1 receptor-deficient mice
View evidence from paper
“M1R−/− mice showed no significant impairments in neurological reflexes, motor coordination, pain sensitivity, and prepulse inhibition.”