Experiments/Radial Water Maze

Source Paper

Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

Joanna L. Jankowsky, Tatiana Melnikova, Daniel J. Fadale, Guilian M. Xu, Hilda H. Slunt et al.

Journal of Neuroscience • 2005

DOI PMC

Radial Water Maze

behavioralmousetransgenic mice overexpressing amyloid precursor protein and/or presenilin-1 and nontransgenic controls

Objective: Assess spatial learning and memory performance in transgenic and control mice using the radial water maze task after 6 months of environmental enrichment or standard housing

This is a Radial Water Maze protocol using mouse as the model organism. The procedure involves 5 procedural steps, 4 equipment items. Extracted from a 2005 paper published in Journal of Neuroscience.

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Replication Essentials

Model and subjects

mouse • transgenic mice overexpressing amyloid precursor protein and/or presenilin-1 and nontransgenic controls • female • 2 months at start of housing condition

Study window

Estimated timing pending

Core workflow

Housing assignment • Differential housing period • Radial water maze testing

Primary readouts

Performance in radial water maze
Memory for platform location in classic Morris water maze
Learning speed for new platform positions in repeated-reversal Morris water maze
Comparison of performance between enriched and standard-housed mice

Key equipment and reagents

Radial Water MazeMorris Water Maze

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Protocol Steps

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Housing assignment

Female transgenic mice overexpressing amyloid precursor protein and/or presenilin-1 and nontransgenic controls were placed into either enriched or standard cages

Note: Assignment occurred at 2 months of age

View evidence from paper

“Female transgenic mice overexpressing amyloid precursor protein and/or presenilin-1 and nontransgenic controls were placed into enriched or standard cages at 2 months of age”

Differential housing period

Mice were maintained in their assigned housing conditions for 6 months

6 months

Note: This period allowed for differential environmental exposure before cognitive testing

View evidence from paper

“tested for cognitive behavior after 6 months of differential housing”