Radial Water Maze
Objective: Assess spatial learning and memory performance in transgenic and control mice using the radial water maze task after 6 months of environmental enrichment or standard housing
Gather these items before starting the experiment. Check off items as you prepare.
3 items available from ConductScience
Estimated: $11,890.00
As an Amazon Associate, we earn from qualifying purchases. Product links help support this free resource.
Protocol Steps
Housing assignment
Female transgenic mice overexpressing amyloid precursor protein and/or presenilin-1 and nontransgenic controls were placed into either enriched or standard cages
Note: Assignment occurred at 2 months of age
View evidence from paper
“Female transgenic mice overexpressing amyloid precursor protein and/or presenilin-1 and nontransgenic controls were placed into enriched or standard cages at 2 months of age”
Differential housing period
Mice were maintained in their assigned housing conditions for 6 months
Note: This period allowed for differential environmental exposure before cognitive testing
View evidence from paper
“tested for cognitive behavior after 6 months of differential housing”
Radial water maze testing
Mice were tested on the radial water maze task to assess spatial learning and memory
Note: Performance was measured across all genotypes
View evidence from paper
“Enrichment significantly improved performance of all genotypes in the radial water maze”
Morris water maze - classic version
Mice were tested on the classic Morris water maze task with a fixed platform location
Note: Memory for platform location was assessed
View evidence from paper
“showed weaker memory for the platform location in the classic Morris water maze”
Morris water maze - repeated-reversal version
Mice were tested on the repeated-reversal version of the Morris water maze where platform positions changed
Note: Speed of learning new platform positions was assessed
View evidence from paper
“learned new platform positions in the repeated-reversals task less quickly than their nontransgenic cagemates”