Recognition Memory Test
Objective: Measured recognition memory deficits in COMT-Val-tg mice and assessed amphetamine effects on memory performance
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Materials1
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Protocol Steps
Recognition Memory Testing
Conducted recognition memory tests on COMT-Val-tg transgenic mice and control mice to measure memory performance deficits
Note: Testing measured recognition memory abilities in transgenic mice overexpressing human COMT-Val polymorphism
View evidence from paper
“Increased COMT enzyme activity in Val-tg mice resulted in disrupted attentional set-shifting abilities, and impaired working and recognition memory”
Amphetamine Administration and Memory Assessment
Administered amphetamine to COMT-Val-tg mice and wild-type controls, then assessed effects on recognition memory performance
Note: Amphetamine had differential effects depending on genotype - ameliorating deficits in Val-tg mice while disrupting memory in wild types
View evidence from paper
“Amphetamine ameliorated recognition memory deficits in COMT-Val-tg mice but disrupted it in wild types, illustrating COMT modulation of the inverted-U relationship between cognition and dopamine”