Recognition Memory Test
Objective: Measured recognition memory deficits in COMT-Val-tg mice and assessed amphetamine effects on memory performance
This is a Recognition Memory Test protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 materials. Extracted from a 2008 paper published in Journal of Neuroscience.
Model and subjects
mouse • COMT-Val-tg transgenic mice and wild-type controls • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Recognition Memory Testing • Amphetamine Administration and Memory Assessment
Primary readouts
- Recognition memory performance
- Memory deficits in COMT-Val-tg mice
- Amphetamine effects on memory performance
- Differential drug response between genotypes
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Recognition Memory Testing
Conducted recognition memory tests on COMT-Val-tg transgenic mice and control mice to measure memory performance deficits
Note: Testing measured recognition memory abilities in transgenic mice overexpressing human COMT-Val polymorphism
View evidence from paper
“Increased COMT enzyme activity in Val-tg mice resulted in disrupted attentional set-shifting abilities, and impaired working and recognition memory”
Amphetamine Administration and Memory Assessment
Administered amphetamine to COMT-Val-tg mice and wild-type controls, then assessed effects on recognition memory performance
Note: Amphetamine had differential effects depending on genotype - ameliorating deficits in Val-tg mice while disrupting memory in wild types
View evidence from paper
“Amphetamine ameliorated recognition memory deficits in COMT-Val-tg mice but disrupted it in wild types, illustrating COMT modulation of the inverted-U relationship between cognition and dopamine”