Rotarod Performance Test
Objective: Assessment of motor coordination and balance in GAT1 knockout mice through rotarod performance testing
This is a Rotarod Performance Test protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2005 paper published in Journal of Neuroscience.
Model and subjects
mouse • GAT1 knockout (mGAT1 KO) mice • unknown • Not specified • Reduced body weight compared to wild-type (female -10%, male -20%)
Study window
Estimated timing pending
Core workflow
Rotarod Performance Assessment
Primary readouts
- Rotarod performance (reduced in GAT1 KO mice)
- Motor coordination assessment
- Balance assessment
- Presence of motor disorders including gait abnormality and tremor
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Rotarod Performance Assessment
Mice were tested on the rotarod apparatus to measure motor coordination and balance. The test revealed reduced rotarod performance in GAT1 knockout mice compared to controls.
Note: Reduced rotarod performance was one of the motor disorders observed in mGAT1 KO mice, along with gait abnormality and constant tremor
View evidence from paper
“Mouse GAT1 (mGAT1) KO mice exhibit motor disorders, including gait abnormality, constant 25-32 Hz tremor, which is aggravated by flunitrazepam, reduced rotarod performance”