Rotarod Performance Test
Objective: Assessment of motor coordination and balance in D2 dopamine receptor-deficient mice using rotarod apparatus
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Equipment1
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Protocol Steps
Rotarod Performance Testing
Mice were tested on the rotarod apparatus to assess motor coordination and balance. Testing was conducted on F2 hybrid D2R-deficient mice, congenic strains, and wild-type controls from different genetic backgrounds.
Note: F2 hybrid D2R−/− mice showed impaired motor coordination compared to wild-type controls. Performance varied by genetic background, with congenic C57BL/6 background showing correction of the impairment. Wild-type 129/SvEv mice had the poorest rotarod ability of all groups tested.
View evidence from paper
“F2 hybrid D2R−/− mice had impaired motor coordination on the rotarod that was corrected in the congenic C57BL/6 background. Wild-type 129/SvEv mice had the poorest rotarod ability of all groups tested”