Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism

Tara L. Spires, Helen E. Grote, Neelash K. Varshney, Patricia M. Cordery, Anton van Dellen et al.

Journal of Neuroscience • 2004

Rotarod Test

behavioralmouseR6/1 transgenic model

Objective: Assessment of motor coordination and balance in transgenic HD mice treated with or without environmental enrichment

Materials & Equipment Checklist

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Rotarod apparatus

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Motor coordination and balance assessment was performed using the rotarod test on transgenic HD mice at 5 months of age

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Note: Test was conducted on both enriched and non-enriched HD mice to assess the effects of environmental enrichment on motor symptoms

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“at 5 months of age, enrichment ameliorates motor symptoms (assessed using the rotarod test)”