Source Paper
Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism
Tara L. Spires, Helen E. Grote, Neelash K. Varshney, Patricia M. Cordery, Anton van Dellen et al.
Journal of Neuroscience • 2004
Rotarod Test
Objective: Assessment of motor coordination and balance in transgenic HD mice treated with or without environmental enrichment
This is a Rotarod Test protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2004 paper published in Journal of Neuroscience.
Model and subjects
mouse • R6/1 transgenic model • unknown • 5 months • not specified
Study window
Estimated timing pending
Core workflow
Rotarod Test Administration
Primary readouts
- Motor coordination performance
- Balance assessment
- Amelioration of motor symptoms by environmental enrichment
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Rotarod Test Administration
Motor coordination and balance assessment was performed using the rotarod test on transgenic HD mice at 5 months of age
Note: Test was conducted on both enriched and non-enriched HD mice to assess the effects of environmental enrichment on motor symptoms
View evidence from paper
“at 5 months of age, enrichment ameliorates motor symptoms (assessed using the rotarod test)”