Rotarod Testing
Objective: Assessment of motor learning and motor function through performance on an accelerating rotating rod
This is a Rotarod Testing protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 2005 paper published in Journal of Neuroscience.
Model and subjects
mouse • YAC128 and wild-type controls • unknown • 2 months to 12 months • Not specified
Study window
Estimated timing pending
Core workflow
Rotarod testing at 2 months of age • Rotarod testing at 12 months of age
Primary readouts
- Motor learning performance
- Motor function
- Ability to learn rotarod task
- Progression of motor deficits with age
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Rotarod testing at 2 months of age
Conduct rotarod testing on YAC128 mice and wild-type controls at 2 months of age to assess motor learning and baseline motor function
Note: Motor learning deficit is evident at this age
View evidence from paper
“Rotarod testing revealed a motor learning deficit at 2 months of age that progresses such that by 12 months of age, untrained YAC128 mice are unable to learn the rotarod task.”
Rotarod testing at 12 months of age
Conduct rotarod testing on untrained YAC128 mice and wild-type controls at 12 months of age to assess progression of motor learning deficits
Note: By 12 months, untrained YAC128 mice are unable to learn the rotarod task
View evidence from paper
“by 12 months of age, untrained YAC128 mice are unable to learn the rotarod task”