Rotarod Testing
Objective: Assessment of motor learning and motor function through performance on an accelerating rotating rod
Gather these items before starting the experiment. Check off items as you prepare.
Equipment1
Not specified • Not specified • Not specified • Not mentioned
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Protocol Steps
Rotarod testing at 2 months of age
Conduct rotarod testing on YAC128 mice and wild-type controls at 2 months of age to assess motor learning and baseline motor function
Note: Motor learning deficit is evident at this age
View evidence from paper
“Rotarod testing revealed a motor learning deficit at 2 months of age that progresses such that by 12 months of age, untrained YAC128 mice are unable to learn the rotarod task.”
Rotarod testing at 12 months of age
Conduct rotarod testing on untrained YAC128 mice and wild-type controls at 12 months of age to assess progression of motor learning deficits
Note: By 12 months, untrained YAC128 mice are unable to learn the rotarod task
View evidence from paper
“by 12 months of age, untrained YAC128 mice are unable to learn the rotarod task”