Social Behavior Assessment
Objective: Evaluation of social abnormalities in Shank3 mutant mice to assess behavioral deficits including social behavior, motor coordination, heat sensitivity, and novelty responses
Protocol Steps
Social Behavior Assessment
Evaluation of social abnormalities in mutant mice
Note: Mice exhibit minimal social abnormalities according to the study results
View evidence from paper
“these mice also exhibit motor-coordination deficits, hypersensitivity to heat, novelty avoidance, altered locomotor response to novelty, and minimal social abnormalities”
Motor Coordination Assessment
Testing of motor-coordination deficits in mutant mice
Note: Motor-coordination deficits were observed in the mutant mice
View evidence from paper
“these mice also exhibit motor-coordination deficits, hypersensitivity to heat, novelty avoidance, altered locomotor response to novelty, and minimal social abnormalities”
Heat Sensitivity Testing
Assessment of hypersensitivity to heat in mutant mice
Note: Hypersensitivity to heat was observed
View evidence from paper
“these mice also exhibit motor-coordination deficits, hypersensitivity to heat, novelty avoidance, altered locomotor response to novelty, and minimal social abnormalities”
Novelty Response Assessment
Evaluation of novelty avoidance and altered locomotor response to novelty
Note: Mice showed novelty avoidance and altered locomotor response to novelty
View evidence from paper
“these mice also exhibit motor-coordination deficits, hypersensitivity to heat, novelty avoidance, altered locomotor response to novelty, and minimal social abnormalities”