Social Behavior Assessment
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Objective: Evaluation of social abnormalities in Shank3 mutant mice to assess behavioral deficits including social behavior, motor coordination, heat sensitivity, and novelty responses
Protocol Steps
1
Social Behavior Assessment
Evaluation of social abnormalities in mutant mice
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Note: Mice exhibit minimal social abnormalities according to the study results
View evidence from paper
“these mice also exhibit motor-coordination deficits, hypersensitivity to heat, novelty avoidance, altered locomotor response to novelty, and minimal social abnormalities”
2
Motor Coordination Assessment
Testing of motor-coordination deficits in mutant mice
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Note: Motor-coordination deficits were observed in the mutant mice
View evidence from paper
“these mice also exhibit motor-coordination deficits, hypersensitivity to heat, novelty avoidance, altered locomotor response to novelty, and minimal social abnormalities”
3
Heat Sensitivity Testing
Assessment of hypersensitivity to heat in mutant mice
Not specified in provided textNot specified in provided text
Note: Hypersensitivity to heat was observed
View evidence from paper
“these mice also exhibit motor-coordination deficits, hypersensitivity to heat, novelty avoidance, altered locomotor response to novelty, and minimal social abnormalities”
4
Novelty Response Assessment
Evaluation of novelty avoidance and altered locomotor response to novelty
Not specified in provided textNot specified in provided text
Note: Mice showed novelty avoidance and altered locomotor response to novelty
View evidence from paper
“these mice also exhibit motor-coordination deficits, hypersensitivity to heat, novelty avoidance, altered locomotor response to novelty, and minimal social abnormalities”