Social Interaction Task
behavioralmouseShank3 null mutant and heterozygous mice
Objective: Assessment of reciprocal social interactions in juvenile and adult mice to evaluate social impairments relevant to autism phenotypes
Protocol Steps
1
Reciprocal Social Interaction Assessment
Mild social impairments were detected, primarily in juveniles during reciprocal interactions
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Note: Assessment conducted in juvenile mice with more pronounced deficits than in adults
View evidence from paper
“Mild social impairments were detected, primarily in juveniles during reciprocal interactions”
2
Three-Chambered Social Task
All genotypes displayed normal adult sociability on the three-chambered task
not specified in provided textnot specified in provided text
Note: Conducted in adult mice; no significant differences detected between genotypes
View evidence from paper
“all genotypes displayed normal adult sociability on the three-chambered task”