Spatial Learning and Memory Task
behavioralmouseNL1 knock-out (KO) mice and wild-type controls
Objective: Assessment of spatial learning and memory deficits in NL1 knock-out mice
Protocol Steps
1
Spatial Learning and Memory Assessment
NL1 knock-out mice were tested in spatial learning and memory tasks to assess cognitive deficits
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Note: Deficits in spatial learning and memory were observed that correlated with impaired hippocampal long-term potentiation
View evidence from paper
“NL1 knock-out (KO) mice display deficits in spatial learning and memory that correlate with impaired hippocampal long-term potentiation”
2
Repetitive Behavior Assessment
NL1 KO mice were assessed for repetitive, stereotyped grooming behavior as a potential autism-relevant abnormality
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Note: A dramatic increase in repetitive, stereotyped grooming behavior was observed in NL1 KO mice
View evidence from paper
“NL1 KO mice exhibit a dramatic increase in repetitive, stereotyped grooming behavior, a potential autism-relevant abnormality”