Spatial Learning and Memory Task
Objective: Assessment of spatial learning and memory deficits in NL1 knock-out mice
This is a Spatial Learning and Memory Task protocol using mouse as the model organism. The procedure involves 2 procedural steps. Extracted from a 2010 paper published in Journal of Neuroscience.
Model and subjects
mouse • NL1 knock-out (KO) mice and wild-type controls • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Spatial Learning and Memory Assessment • Repetitive Behavior Assessment
Primary readouts
- Spatial learning and memory performance
- Hippocampal long-term potentiation
- Repetitive grooming behavior frequency and duration
- NMDA/AMPA ratio at corticostriatal synapses
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Spatial Learning and Memory Assessment
NL1 knock-out mice were tested in spatial learning and memory tasks to assess cognitive deficits
Note: Deficits in spatial learning and memory were observed that correlated with impaired hippocampal long-term potentiation
View evidence from paper
“NL1 knock-out (KO) mice display deficits in spatial learning and memory that correlate with impaired hippocampal long-term potentiation”
Repetitive Behavior Assessment
NL1 KO mice were assessed for repetitive, stereotyped grooming behavior as a potential autism-relevant abnormality
Note: A dramatic increase in repetitive, stereotyped grooming behavior was observed in NL1 KO mice
View evidence from paper
“NL1 KO mice exhibit a dramatic increase in repetitive, stereotyped grooming behavior, a potential autism-relevant abnormality”