Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome

Paolo Moretti, Jonathan M. Levenson, Fortunato Battaglia, Richard Atkinson, Ryan Teague et al.

Journal of Neuroscience • 2006

Spatial Memory Task

behavioralmouseMecp2 308 mutant mice

Objective: Assessment of hippocampus-dependent spatial memory in Mecp2 mutant mice to determine if learning deficits are present in these animals

Hippocampus-dependent spatial memory was tested in Mecp2 308 mutant mice

Not specifiedNot specified

Note: This was one of three memory types assessed; spatial memory was significantly impaired in Mecp2 308/Y mutant males

View evidence from paper

“Hippocampus-dependent spatial memory, contextual fear memory, and social memory were significantly impaired in Mecp2 308 mutant males”