Stress Response Assessment
Objective: Evaluated stress reactivity and response differences between COMT-Val-tg and COMT-null mice to assess the role of COMT gene in stress responses and affective functions
This is a Stress Response Assessment protocol using mouse as the model organism. The procedure involves 2 procedural steps. Extracted from a 2008 paper published in Journal of Neuroscience.
Model and subjects
mouse • COMT-Val-tg and COMT-null transgenic mice • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Stress Response Assessment • Comparative Analysis
Primary readouts
- Stress reactivity differences between genotypes
- Blunted stress responses in Val-tg mice
- Increased stress responses in COMT-null mice
- Pain sensitivity measurements
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Stress Response Assessment
Evaluated stress reactivity and response differences between COMT-Val-tg and COMT-null mice
Note: Specific stress assessment methodology not detailed in provided text
View evidence from paper
“Increased COMT enzyme activity in Val-tg mice resulted in disrupted attentional set-shifting abilities, and impaired working and recognition memory, but blunted stress responses and pain sensitivity”
Comparative Analysis
Compared stress responses between Val-tg mice and COMT-null mice to identify differences in stress reactivity
Note: COMT disruption increased stress responses compared to Val-tg mice
View evidence from paper
“Conversely, COMT disruption improved working memory, but increased stress responses and pain sensitivity”