Stress Response Assessment
behavioralmouseCOMT-Val-tg and COMT-null transgenic mice
Objective: Evaluated stress reactivity and response differences between COMT-Val-tg and COMT-null mice to assess the role of COMT gene in stress responses and affective functions
Protocol Steps
1
Stress Response Assessment
Evaluated stress reactivity and response differences between COMT-Val-tg and COMT-null mice
Not specifiedNot specified
Note: Specific stress assessment methodology not detailed in provided text
View evidence from paper
“Increased COMT enzyme activity in Val-tg mice resulted in disrupted attentional set-shifting abilities, and impaired working and recognition memory, but blunted stress responses and pain sensitivity”
2
Comparative Analysis
Compared stress responses between Val-tg mice and COMT-null mice to identify differences in stress reactivity
Not specifiedNot specified
Note: COMT disruption increased stress responses compared to Val-tg mice
View evidence from paper
“Conversely, COMT disruption improved working memory, but increased stress responses and pain sensitivity”