Source Paper
Prenatal and early postnatal cannabis exposure interactions with adolescent chronic stress on anxiety-like, depression-like, and risk-taking behaviour.
Peterson CS, Ifionu I, Hamood F, Semizeh H, Ali A et al.
Psychopharmacology (Berl) • 2026
Sucrose Preference Test
Objective: Measures anhedonia-like behavior in mice
This is a Sucrose Preference Test protocol using mouse as the model organism. The procedure involves 3 procedural steps, 1 materials. Extracted from a 2026 paper published in Psychopharmacology (Berl).
Model and subjects
mouse • PD58
Study window
Estimated timing pending
Core workflow
Subject preparation • Stress exposure period • Sucrose preference test
Primary readouts
- anhedonia-like behavior
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Subject preparation
Use offspring from mouse dams that orally consumed THC in whole cannabis oil daily from GD1-PD10
Note: Subjects were exposed to chronic mild unpredictable stress throughout adolescence
View evidence from paper
“Mouse dams orally consumed 5 mg/kg THC in whole cannabis oil daily from GD1-PD10”
Stress exposure period
Expose offspring to chronic mild unpredictable stress throughout adolescence
View evidence from paper
“Offspring were exposed to chronic mild unpredictable stress throughout adolescence (PD28-56)”
Sucrose preference test
Challenge mice with sucrose preference test as part of behavioral battery to measure anhedonia-like behavior
Note: Conducted from PD58 as part of battery of behavioral tests
View evidence from paper
“From PD58, mice were challenged with a battery of tests to measure anxiety-like (elevated plus maze, open field test), stress coping (forced swim test, tail suspension test), anhedonia-like (sucrose preference)”