Survival Analysis
Objective: Measurement of survival duration in treated versus untreated R6/2 transgenic mice to assess dose-dependent effects of sodium butyrate on lifespan and neuropathological outcomes
Gather these items before starting the experiment. Check off items as you prepare.
Materials1
Not specified • Not specified • Not specified • Not specified
As an Amazon Associate, we earn from qualifying purchases. Product links help support this free resource.
Protocol Steps
Animal treatment initiation
R6/2 transgenic mice were treated with sodium butyrate at varying doses to assess dose-dependent effects on survival
Note: Treatment was dose-dependent; specific dosing regimen not detailed in provided text
View evidence from paper
“Pharmacological treatment using the histone deacetylase inhibitor sodium butyrate to modulate transcription significantly extended survival in a dose-dependent manner”
Survival monitoring
Survival duration was monitored and recorded for treated versus untreated R6/2 transgenic mice throughout the study period
Note: Comparison made between treated and untreated control groups
View evidence from paper
“significantly extended survival in a dose-dependent manner, improved body weight and motor performance, and delayed the neuropathological sequelae in the R6/2 transgenic mouse model of HD”