T-Maze
Objective: Assess spatial learning and decision-making in mice to evaluate cognitive function and detect learning impairments
This is a T-Maze protocol using mouse as the model organism. The procedure involves 3 procedural steps, 1 equipment items. Extracted from a 1999 paper published in Journal of Neuroscience.
Model and subjects
mouse • R6/2 transgenic and wild-type littermates • unknown • 3 to 14.5 weeks of age • Not specified
Study window
~14.5 week study window
Core workflow
Subject Selection and Grouping • T-maze Task Administration • Longitudinal Assessment
Primary readouts
- Spatial learning performance in T-maze
- Decision-making accuracy
- Progressive deterioration in cognitive function
- Age of onset of learning impairments
Key equipment and reagents
Verified items
0
Direct vendor links
0
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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- Verify the animal model, intervention setup, and collection timepoints against the source paper.
- Check that every direct vendor link matches the exact specification your lab plans to run.
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- Work through the protocol steps in order and use the inline vendor chips only when you need to source or verify an item.
- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
Start here. The step list is optimized for running the experiment, with direct vendor links available inline when you need to source a cited item.
Subject Selection and Grouping
Behavioral testing was performed on R6/2 transgenic mice and their wild-type littermates using separate groups of mice for each test
Note: Testing conducted between 3 and 14.5 weeks of age
View evidence from paper
“Behavioral testing was performed on R6/2 transgenic mice and their wild-type littermates between 3 and 14.5 weeks of age, using separate groups of mice for each test”
T-maze Task Administration
Mice were tested in the T-maze task to assess spatial learning and decision-making abilities
Note: Task demands differed from other cognitive tests used in the study
View evidence from paper
“R6/2 mice displayed progressive deterioration in specific aspects of learning in the Morris water maze, visual cliff, two-choice swim tank, and T-maze tasks”
Longitudinal Assessment
Cognitive performance was assessed across multiple time points to detect progressive learning impairments
Note: Age of onset and progression of deficits differed depending on particular task demands
View evidence from paper
“between 3.5 and 8 weeks of age, R6/2 mice displayed progressive deterioration in specific aspects of learning in the Morris water maze, visual cliff, two-choice swim tank, and T-maze tasks”