Source Paper
Prenatal and early postnatal cannabis exposure interactions with adolescent chronic stress on anxiety-like, depression-like, and risk-taking behaviour.
Peterson CS, Ifionu I, Hamood F, Semizeh H, Ali A et al.
Psychopharmacology (Berl) • 2026
Tail Suspension Test
Objective: Measures stress coping behavior in mice
This is a Tail Suspension Test protocol using mouse as the model organism. The procedure involves 3 procedural steps. Extracted from a 2026 paper published in Psychopharmacology (Berl).
Model and subjects
mouse • PD58 onwards
Study window
Estimated timing pending
Core workflow
Prenatal and postnatal THC exposure • Chronic mild unpredictable stress exposure • Behavioral testing battery initiation
Primary readouts
- stress coping behavior
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Prenatal and postnatal THC exposure
Mouse dams orally consumed THC in whole cannabis oil daily during gestation and early postnatal period
Note: 5 mg/kg THC dose in whole cannabis oil
View evidence from paper
“Mouse dams orally consumed 5 mg/kg THC in whole cannabis oil daily from GD1-PD10”
Chronic mild unpredictable stress exposure
Offspring were exposed to chronic mild unpredictable stress throughout adolescence
Note: Applied during adolescent period
View evidence from paper
“Offspring were exposed to chronic mild unpredictable stress throughout adolescence (PD28-56)”
Behavioral testing battery initiation
Mice were challenged with a battery of behavioral tests including tail suspension test
Note: Part of comprehensive behavioral assessment including anxiety-like, stress coping, anhedonia-like, risk-taking, and social motivation tests
View evidence from paper
“From PD58, mice were challenged with a battery of tests to measure anxiety-like (elevated plus maze, open field test), stress coping (forced swim test, tail suspension test)”