Tone Fear Conditioning
Objective: Assessment of associative learning through tone-dependent fear response in mice to evaluate whether human glial progenitor cell engraftment enhances learning and synaptic plasticity
This is a Tone Fear Conditioning protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2013 paper published in Cell stem cell.
Model and subjects
mouse • immunodeficient mice (neonatal) • unknown • neonatal at engraftment; adult at testing • not specified
Study window
Estimated timing pending
Core workflow
Tone Fear Conditioning Assessment
Primary readouts
- Tone-dependent fear response
- Associative learning ability
- Comparison of learning between human GPC-engrafted mice and murine GPC-engrafted mice
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Tone Fear Conditioning Assessment
Mice were assessed for tone fear conditioning as a measure of associative learning. This involved exposing mice to a tone stimulus paired with an unconditioned stimulus to measure fear-related responses.
Note: This was one of multiple learning assessments performed alongside Barnes maze navigation, object-location memory, and contextual fear conditioning
View evidence from paper
“their learning, as assessed by Barnes maze navigation, object-location memory, and both contextual and tone fear conditioning”