Two-Choice Swim Tank
Objective: Assess discrimination learning ability in mice using a two-choice swimming paradigm to evaluate cognitive function sensitive to frontostriatal and hippocampal function
This is a Two-Choice Swim Tank protocol using mouse as the model organism. The procedure involves 3 procedural steps, 1 equipment items. Extracted from a 1999 paper published in Journal of Neuroscience.
Model and subjects
mouse • R6/2 transgenic and wild-type littermates • unknown • 3 to 14.5 weeks of age • Not specified
Study window
~14.5 week study window
Core workflow
Subject preparation and grouping • Two-choice swim tank discrimination learning task • Assessment period
Primary readouts
- Discrimination learning performance
- Progressive deterioration in learning ability
- Age of onset of cognitive deficits
- Progression rate of learning impairments
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Subject preparation and grouping
R6/2 transgenic mice and their wild-type littermates were assigned to behavioral testing groups
Note: Separate groups of mice were used for each test to avoid confounding effects of repeated testing
View evidence from paper
“Behavioral testing was performed on R6/2 transgenic mice and their wild-type littermates between 3 and 14.5 weeks of age, using separate groups of mice for each test”
Two-choice swim tank discrimination learning task
Mice performed discrimination learning task in the two-choice swim tank requiring selection between two options during swimming
Note: Task was used to assess cognitive performance and detect learning impairments
View evidence from paper
“two-choice swim tank, and T-maze tasks. Behavioral testing was performed on R6/2 transgenic mice and their wild-type littermates between 3 and 14.5 weeks of age”
Assessment period
Behavioral testing conducted across multiple age timepoints to track progressive changes in cognitive performance
Note: Progressive deterioration in learning was assessed between 3.5 and 8 weeks of age
View evidence from paper
“between 3.5 and 8 weeks of age, R6/2 mice displayed progressive deterioration in specific aspects of learning in the Morris water maze, visual cliff, two-choice swim tank, and T-maze tasks”