Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP

Jill L Silverman, Seda S Tolu, Charlotte L Barkan, Jacqueline N Crawley

Neuropsychopharmacology • 2009

Ultrasonic Vocalization Recording

behavioralmouseBTBR T+tf/J (BTBR) and C57BL/6J (B6)

Objective: Assessment of ultrasonic vocalization patterns in BTBR mice as part of autism phenotype characterization

Materials & Equipment Checklist

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Ultrasonic vocalization recording equipment

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Record and analyze ultrasonic vocalization patterns in BTBR mice to characterize autism-related communication deficits

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Note: BTBR mice show unusual patterns of ultrasonic vocalization as a phenotype analogous to communication deficits in autism

View evidence from paper

“unusual patterns of ultrasonic vocalization, and high levels of repetitive self-grooming. These phenotypes offer straightforward behavioral assays”