Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome

Gal Hacohen-Kleiman, Shlomo Sragovich, Gidon Karmon, Andy Y. L. Gao, Iris Grigg et al.

Journal of Clinical Investigation • 2018

Vocalization Assessment

behavioralmouseAdnp+/- (haploinsufficient)

Objective: Measurement of vocalization impediments in Adnp+/- mice following NAP administration

Materials & Equipment Checklist

1 item

Gather these items before starting the experiment. Check off items as you prepare.

NAP (NAPV SIP Q, also known as CP201)

Coronis Neurosciences • Not specified • CP201 • Not specified

As an Amazon Associate, we earn from qualifying purchases. Product links help support this free resource.

Daily NAP administration to Adnp+/- mice via systemic or nasal routes

Daily treatmentNot specified

Note: Treatment administered both systemically and nasally

View evidence from paper

“all of which were partially reversed by daily NAP administration (systemic/nasal)”

Assessment of vocalization impediments in Adnp+/- mice

Not specifiedNot specified

Note: Vocalization impediments were among the behavioral phenotypes measured

View evidence from paper

“Adnp +/- mice further exhibited global developmental delays, vocalization impediments, gait and motor dysfunctions”