Experiments/Vocalization Assessment

Source Paper

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome

Gal Hacohen-Kleiman, Shlomo Sragovich, Gidon Karmon, Andy Y. L. Gao, Iris Grigg et al.

Journal of Clinical Investigation • 2018

DOI PMC

Vocalization Assessment

behavioralmouseAdnp+/- (haploinsufficient)

Objective: Measurement of vocalization impediments in Adnp+/- mice following NAP administration

This is a Vocalization Assessment protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 materials. Extracted from a 2018 paper published in Journal of Clinical Investigation.

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Replication Essentials

Model and subjects

mouse • Adnp+/- (haploinsufficient) • unknown • Not specified • Not specified

Study window

Estimated timing pending

Core workflow

NAP Administration • Vocalization Assessment

Primary readouts

Vocalization impediments
Global developmental delays
Gait and motor dysfunctions
Social and object memory impairments

Key equipment and reagents

NAP (NAPV SIP Q, also known as CP201)

Procurement Snapshot

Verified items

Direct vendor links

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Before You Start

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Protocol Steps

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NAP Administration

Daily NAP administration to Adnp+/- mice via systemic or nasal routes

Daily treatmentNot specified

Note: Treatment administered both systemically and nasally

View evidence from paper

“all of which were partially reversed by daily NAP administration (systemic/nasal)”