Source Paper
Running enhances spatial pattern separation in mice
David J. Creer, Carola Romberg, Lisa M. Saksida, Henriette van Praag, Timothy J. Bussey
Proceedings of the National Academy of Sciences • 2010
Voluntary Running Wheel
Objective: Assessment of the effects of voluntary running exercise on cognitive performance and neurogenesis in adult and aged mice, specifically measuring spatial pattern separation ability
This is a Voluntary Running Wheel protocol using mouse as the model organism. The procedure involves 3 procedural steps, 1 equipment items. Extracted from a 2010 paper published in Proceedings of the National Academy of Sciences.
Model and subjects
mouse • C57BL/6 • male • Adult (3 months old) and aged (22 months old)
Study window
Estimated timing pending
Core workflow
Animal grouping and housing • Voluntary running exercise • Spatial pattern separation testing
Primary readouts
- Spatial pattern separation ability (discrimination between locations of two adjacent identical stimuli)
- Neurogenesis levels in the dentate gyrus
- Correlation between improved spatial discrimination and increased neurogenesis
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Animal grouping and housing
Adult (3 months old) and very aged (22 months old) male C57BL/6 mice were used in the study
Note: Two distinct age groups were tested to compare effects of running on younger versus older animals
View evidence from paper
“voluntary running enhanced the ability of adult (3 months old) male C57BL/6 mice to discriminate between the locations of two adjacent identical stimuli. In contrast, very aged (22 months old) mice had impaired spatial discrimination”
Voluntary running exercise
Mice were provided access to running wheels for voluntary exercise
Note: Running was voluntary, allowing mice to self-regulate exercise activity
View evidence from paper
“voluntary running enhanced the ability of adult (3 months old) male C57BL/6 mice to discriminate between the locations of two adjacent identical stimuli”
Spatial pattern separation testing
Mice were tested on their ability to discriminate between the locations of two adjacent identical stimuli
Note: This test measures spatial pattern separation, a specific cognitive function
View evidence from paper
“voluntary running enhanced the ability of adult (3 months old) male C57BL/6 mice to discriminate between the locations of two adjacent identical stimuli”