Voluntary Wheel Running
Objective: Assessment of the effects of voluntary exercise on hippocampal neurogenesis and the role of TrkB receptor in mediating neurogenic responses to wheel running and antidepressant treatment
Gather these items before starting the experiment. Check off items as you prepare.
Equipment1
Not explicitly stated in provided text • Not mentioned • Not mentioned • Not mentioned
As an Amazon Associate, we earn from qualifying purchases. Product links help support this free resource.
Protocol Steps
Voluntary wheel running exposure
Mice are exposed to voluntary wheel running as an exercise intervention to assess effects on hippocampal neurogenesis
Note: This intervention is compared to antidepressant administration and control conditions
View evidence from paper
“Adult hippocampal neurogenesis is stimulated by chronic administration of antidepressants and by voluntary exercise”
Assessment of neurogenesis response
Measurement of proliferation and neurogenesis in dentate gyrus neural progenitor cells following wheel running exposure
Note: TrkB-deficient mice show impaired proliferation and neurogenesis with no increase observed following wheel running
View evidence from paper
“When exposed to chronic AD or wheel running, no increase in proliferation or neurogenesis is observed”