Voluntary Wheel Running
Objective: Assessment of the effects of voluntary exercise on hippocampal neurogenesis and the role of TrkB receptor in mediating neurogenic responses to wheel running and antidepressant treatment
This is a Voluntary Wheel Running protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 2008 paper published in Neuron.
Model and subjects
mouse • Not explicitly stated in provided text • unknown • Not explicitly stated in provided text • Not explicitly stated in provided text
Study window
Estimated timing pending
Core workflow
Voluntary wheel running exposure • Assessment of neurogenesis response
Primary readouts
- Proliferation of neural progenitor cells in dentate gyrus
- Neurogenesis in hippocampus
- Behavioral sensitivity to antidepressive treatment
- Depression and anxiety-like behaviors
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Voluntary wheel running exposure
Mice are exposed to voluntary wheel running as an exercise intervention to assess effects on hippocampal neurogenesis
Note: This intervention is compared to antidepressant administration and control conditions
View evidence from paper
“Adult hippocampal neurogenesis is stimulated by chronic administration of antidepressants and by voluntary exercise”
Assessment of neurogenesis response
Measurement of proliferation and neurogenesis in dentate gyrus neural progenitor cells following wheel running exposure
Note: TrkB-deficient mice show impaired proliferation and neurogenesis with no increase observed following wheel running
View evidence from paper
“When exposed to chronic AD or wheel running, no increase in proliferation or neurogenesis is observed”