Genetic Dissection of the Role of Catechol-<i>O</i>-Methyltransferase in Cognition and Stress Reactivity in Mice

Francesco Papaleo, Jacqueline N. Crawley, Jian Song, Barbara K. Lipska, Jim Pickel et al.

Journal of Neuroscience • 2008

DOI PMC

Working Memory Test

behavioralmouseCOMT-Val-tg and COMT-null mice

Objective: Evaluated working memory performance in COMT-Val-tg and COMT-null mice to assess the role of catechol-O-methyltransferase in cognitive function

Protocol Steps

Working Memory Assessment

Evaluated working memory performance in COMT-Val-tg and COMT-null mice as part of behavioral testing

Not specifiedNot specified

Note: Results showed impaired working memory in COMT-Val-tg mice and improved working memory in COMT-null mice

View evidence from paper

“Increased COMT enzyme activity in Val-tg mice resulted in disrupted attentional set-shifting abilities, and impaired working and recognition memory”