Source Paper
Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention
Shi W, Bian L, Yu M, Wang J, Gao M et al.
Adv Sci (Weinh) • 2025
Grip Strength Test
Objective: To measure grip strength as an indicator of physical performance in aged mice
This is a Grip Strength Test protocol using mice as the model organism. The procedure involves 4 procedural steps, 1 equipment items, 2 materials. Extracted from a 2025 paper published in Adv Sci (Weinh).
Model and subjects
mice • not specified • not specified • 20 months old (aged) and 10 months old (young reference) • 6
Study window
Estimated timing pending
Core workflow
Baseline measurements • Treatment administration • Biweekly assessments
Primary readouts
- Grip strength (percentage change from baseline)
- Physical performance improvement
Key equipment and reagents
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Protocol Steps
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Baseline measurements
Obtain baseline grip strength measurements prior to treatment across all groups
View evidence from paper
“Prior to treatment, baseline measurements of grip strength, fatigue resistance, and motor coordination were obtained across all groups”
Treatment administration
Administer intravenous injections of nmEVs or PBS twice weekly for 16 total doses over 2 months
View evidence from paper
“Aged mice then received intravenous injections of either nmEVs or PBS twice weekly for a total of 16 doses over 2 months”
Biweekly assessments
Assess physical performance including grip strength biweekly throughout treatment course
View evidence from paper
“Throughout the treatment course, physical performance was assessed biweekly”
Data analysis
Present grip strength data as percentage change from baseline before treatment
View evidence from paper
“Grip strength was significantly increased in nmEV-treated mice; data are shown as the change in percentage from baseline before treatment”