Source Paper
Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention
Shi W, Bian L, Yu M, Wang J, Gao M et al.
Adv Sci (Weinh) • 2025
Grip Strength Test
behavioralmicenot specified
Objective: To measure grip strength as an indicator of physical performance in aged mice
Materials & Equipment Checklist
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Protocol Steps
1
Baseline measurements
Obtain baseline grip strength measurements prior to treatment across all groups
View evidence from paper
“Prior to treatment, baseline measurements of grip strength, fatigue resistance, and motor coordination were obtained across all groups”
2
Treatment administration
Administer intravenous injections of nmEVs or PBS twice weekly for 16 total doses over 2 months
View evidence from paper
“Aged mice then received intravenous injections of either nmEVs or PBS twice weekly for a total of 16 doses over 2 months”
3
Biweekly assessments
Assess physical performance including grip strength biweekly throughout treatment course
View evidence from paper
“Throughout the treatment course, physical performance was assessed biweekly”
4
Data analysis
Present grip strength data as percentage change from baseline before treatment
View evidence from paper
“Grip strength was significantly increased in nmEV-treated mice; data are shown as the change in percentage from baseline before treatment”