Source Paper
Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy
Zhou Z, Yu X, Tian E, Guo Z, Chen J et al.
CNS Neurosci Ther • 2026
Radial 8-Arm Maze
behavioralmiceC57BL/6J
Objective: Assess spatial working memory and navigation performance using an 8-arm radial maze task
Materials & Equipment Checklist
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Protocol Steps
1
Weight reduction
Reduce animals' body weight to 85% of free-feeding weight while maintaining ad libitum water access
not specified
View evidence from paper
“the animals' body weight was maintained at 85% of their free-feeding weight, with water available ad libitum”
2
Acclimatization phase
Allow mice to explore the maze with all arms baited with one food pellet at the distal terminal
10 min sessions, twice daily over three consecutive days
View evidence from paper
“all arms were baited with one food pellet placed at the distal terminal, allowing mice to explore the maze for 10 min. This process was conducted twice daily over three consecutive days”
3
Testing sessions
Conduct formal testing with mice allowed to visit all 8 baited arms within the time limit
5 min per session, 20 testing sessions during 10 consecutive days, with two sessions per day spaced by a minimum of 2 h
View evidence from paper
“the mice underwent 20 testing sessions during 10 consecutive days, with two sessions per day spaced by a minimum of 2 h. During each testing session, the animals were allowed to visit all 8 baited arms within 5 min”