Source Paper
Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy
Zhou Z, Yu X, Tian E, Guo Z, Chen J et al.
CNS Neurosci Ther • 2026
Radial 8-Arm Maze
Objective: Assess spatial working memory and navigation performance using an 8-arm radial maze task
This is a Radial 8-Arm Maze protocol using mice as the model organism. The procedure involves 3 procedural steps, 1 equipment items, 1 materials. Extracted from a 2026 paper published in CNS Neurosci Ther.
Model and subjects
mice • C57BL/6J • male • 8 weeks old • not specified
Study window
~15 minutes hands-on
Core workflow
Weight reduction • Acclimatization phase • Testing sessions
Primary readouts
- Repetition errors (re-entering previously visited arms)
- Omission errors (failing to visit an arm)
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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- Verify the animal model, intervention setup, and collection timepoints against the source paper.
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Protocol Steps
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Weight reduction
Reduce animals' body weight to 85% of free-feeding weight while maintaining ad libitum water access
View evidence from paper
“the animals' body weight was maintained at 85% of their free-feeding weight, with water available ad libitum”
Acclimatization phase
Allow mice to explore the maze with all arms baited with one food pellet at the distal terminal
View evidence from paper
“all arms were baited with one food pellet placed at the distal terminal, allowing mice to explore the maze for 10 min. This process was conducted twice daily over three consecutive days”
Testing sessions
Conduct formal testing with mice allowed to visit all 8 baited arms within the time limit
View evidence from paper
“the mice underwent 20 testing sessions during 10 consecutive days, with two sessions per day spaced by a minimum of 2 h. During each testing session, the animals were allowed to visit all 8 baited arms within 5 min”