Source Paper
Lack of striatal-enriched protein tyrosine phosphatase affected the serotonin system, behavior, and brain morphology in mice
Moskaliuk V, Komleva P, Khotskin N, Arefieva A, Shevelev O et al.
Front Psychiatry • 2026
Startle Test
Objective: To measure acoustic startle response magnitude and prepulse inhibition in mice
This is a Startle Test protocol using mice as the model organism. The procedure involves 4 procedural steps, 2 equipment items. Extracted from a 2026 paper published in Front Psychiatry.
Model and subjects
mice • C57BL/6-Ptpn5_KO and C57BL/6 (wild type) • male • 2-month-old • not specified
Study window
Estimated timing pending
Core workflow
Perform startle test after rest period • Conduct six test sessions • Measure startle response
Primary readouts
- Startle response amplitude (AP)
- Prepulse inhibition percentage calculated as: PPI = (AP - APP)/AP × 100%
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
Confirm first
- Verify the animal model, intervention setup, and collection timepoints against the source paper.
- Check that every direct vendor link matches the exact specification your lab plans to run.
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- Work through the protocol steps in order and use the inline vendor chips only when you need to source or verify an item.
- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
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Perform startle test after rest period
The startle test was performed after 1 month of rest following other behavioral tests
View evidence from paper
“After 1 month of rest, the startle test was performed”
Conduct six test sessions
The test consisted of six sessions, each including either a single pulse (P) or a pulse with a prepulse (PP)
View evidence from paper
“The test consisted of six sessions, each of which included either a single pulse (P) or a pulse with a prepulse (PP)”
Measure startle response
Measure the magnitude of acoustic startle response using accelerometer sensor starting 20 ms after the main signal
View evidence from paper
“The magnitude of an acoustic startle response was measured with an accelerometer sensor starting 20 ms after the main signal”
Calculate final parameter
Take the average potential throughout the measurement as the final parameter
View evidence from paper
“The average potential throughout the measurement was taken as the final parameter”